The TBC1D7 Antibody, Biotin conjugated from MyBioSource.com is a Rabbit Polyclonal antibody to TBC1D7, and TBC1D7-LOC100130357. This antibody recognizes Human antigen. The TBC1D7 Antibody, Biotin conjugated has been validated for the following applications: EIA, Immunoassay, and ELISA.
Description
Component of the TSC-TBC complex, that contains TBC1D7 in addition to the TSC1-TSC2 complex and consists of the functional complex possessing GTPase-activating protein (GAP) activity toward RHEB in response to alterations in specific cellular growth conditions. The small GTPase RHEB is a direct activator of the protein kinase activity of mTORC1 and the TSC-TBC complex acts as a negative regulator of mTORC1 signaling cascade by acting as a GAP for RHEB. Participates in the proper sensing of growth factors and glucose, but not amino acids, by mTORC1. It is unclear whether TBC1D7 acts as a GTPase-activating protein and additional studies are required to answer this question